Endocannabinoid overactivity and intestinal inflammation
نویسندگان
چکیده
منابع مشابه
Prom1 Function in Development, Intestinal Inflammation, and Intestinal Tumorigenesis
Prom1/CD133 has been identified in colorectal, hepatocellular, and pancreatic cancer as a cancer stem cell marker and has been used as such to predict colon cancer recurrence in humans. Its potential molecular function as well as its role as a marker of intestinal regeneration is still not fully known. We evaluated the role of Prom1 in intestinal regeneration in inflammatory bowel disease (IBD)...
متن کاملCommentary: “Prom1 Function in Development, Intestinal Inflammation, and Intestinal Tumorigenesis”
A large body of publications mentioning prominin-1 (Prom1, CD133) is related to its use as a stem and cancer stem cell marker (1). Besides progenitor cells, its expression is widespread throughout terminally differentiated cells as those found in glandular organs (e.g., pancreas) and retina (2). Yet, the amino acid sequence of Prom1 didn’t reveal any motif or potential enzymatic activity that c...
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Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis, contribute to significant morbidity and mortality globally. Despite an increase in incidence, IBD onset is still poorly understood. Mouse models of IBD recapitulate several aspects of human disease, but limited accessibility for live imaging and the lack of forward genetics highlight the need for new model ...
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The activation of specific cytosolic pathogen recognition receptors, the nucleotide-binding-oligomerization-domain- (NOD-) like receptors (NLRs), leads to the assembly of the inflammasome, a multimeric complex platform that activates caspase-1. The caspase-1 pathway leads to the upregulation of important cytokines from the interleukin (IL)-1 family, IL-1β , and IL-18, with subsequent activation...
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ژورنال
عنوان ژورنال: Gut
سال: 2006
ISSN: 0017-5749
DOI: 10.1136/gut.2005.090472